Kadam a thesis submitted in partial fulfilment for the requirements for the degree of msc by research at the university of central lancashire january 20. Nanoemulsion and nanoemulgel as a topical 44 provides numerous advantages over other carrier such as polymeric nanoparticle and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system to enhance the longer shelf. The present study was thus aimed at development of a novel oilinwater ow nanoemulsion ne system having ability to function as carrier for poorly soluble drugs with clarithromycin as a model antibiotic. A novel approach in various pharmaceutical applications jyotsana suyal uttranchal institute of pharmaceutical sciences, dehradun, uttarakhand, india 248007 article history. Preparation and evaluation of oilinwater selfnanoemulsifying. A thesis submitted for the degree of doctor of philosophy at. Pdf current state of nanoemulsions in drug delivery. Nanoemulsions as vehicle for topical administration of glycyrrhetic acid characterization and in vitro and in vivo evaluation. On a mass scale, this merging effectively disintegrates the membrane and kills the pathogen. Nanoemulsions are nanosized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. Preparation and evaluation of nanoemulsion formulation by using spontaneous emulsification deepa dhiman, amit kumar pal, aman mittal, sunit saini department of pharmacy, smt. For each phase diagram, oil and specific s mix ratio was mixed thoroughly in different volume ratios from 1. Production and characterization of cosmetic nanoemulsions. International journal of research in pharmaceutical and nano.
The emulsions contained neem oil and surfactant with ratios of 1. Their small size leads to useful properties such as high surface area per unit volume. Nanoemulsion based targeting in cancer therapeutics. Pdf nanoemulsions have attracted great attention in research, dosage form design. Formulation and evaluation of aciclovir loaded novel gelfor. Access to the contents of this doctoral thesis and its use must respect the. Praveen kumar g, divya a 2015 nanoemulsion based targeting in cancer therapeutics. Microstructure group school of chemical engineering college of engineering and physical sciences university of birmingham february 2015. If refractive index of nanoemulsion has equal refractive index as that of water, then the nanoemulsion is considered to have transparent nature 2. Preparation and evaluation of nanoemulsion formulation by. These two regions allow them to interact with the polar aqueous phase and the nonpolar oil phase. The droplets size of nano emulsion is between 20 to 500 nm. The primary objective of this thesis to achieve gelation in oilwas inwater ow nes.
Nanoemulsion formulations for brain tumour therapy by alisha n. Nanoemulsions as delivery systems of food ingredients. Essential oil nanoemulsions prepared with natural emulsifiers for. The samples were then observed for phase separation and drug precipitation. If the volume fraction of the dispersed phase is small, the droplet of the nanoemulsion is spherical. A new concept of delivery system nitin sharma 1, mayank bansal 1, sharad visht 1, pk sharma 1, gt kulkarni 2 1 department of pharmaceutical technology, meerut inst. A thesis submitted to the university of birmingham for the degree of doctor of philosophy.
Novel formulations of antioxidant and antiinflammatory drugs to ameliorate ischemic damage measured in vitro philip kin liang master of science graduate department of physiology university of toronto 2009 abstract the two of major pathways that cause ischemic damage are oxidative stress and inflammation. These are the thermodynamically stable isotropic system in. Benign prostatic hyperplasia, dutasteride, nanoemulsion, selflife, stability study, tem introduction benign prostatic hyperplasia bph is the nonmalignant enlargement of the prostate gland resulting due to overproliferation of the stromal and glandular elements of the prostate 1. Assigned by loreal paris, fr with the us patent number of 6,689,371 simonnet et al. Nanoemulsion droplets when encounter lipids on a bacterial cell wall or a virus envelope, the surface tension of the nanoemulsion droplets forces the lipids of the organism and oil contained in the nanoemulsion droplets to merge. The volume was made up to 100 ml using methanol to prepare stock solution of 100 gml. The phase diagrams constructed for the systems at various ratios 1. Vmd given in table 1 is the average diameter based on unit volume area of a particle and smd the average diameter based on the unit surface of a particle. Then the absorbance was measured by uvvisible spectrophotometer genesys 10s at the maximum wavelength of 417 nm. Sz ucs maria, budai szabolcs, er os istvan, gelemulsion systems i.
High amount of surfactant is required to stabilize the droplets formed. Transparent nanoemulsion less than 100 nm based on fluid nonionic. The sample injection volume was 20 l and schizandrol. The abovementioned surfactant molecules, in most cases, comprise of a polar head which make up a small fraction of the molecular volume and a nonpolar tail. The sparingly water soluble property of majority of medicinally significant drugs acts as a potential barrier towards its utilization for therapeutic purpose. Doylea nanoemulsions are kinetically stable liquidinliquid dispersions with droplet sizes on the order of 100 nm. Nanoemulsion and nanoemulgel as a topical 44 provides numerous advantages over other carrier such as polymeric nanoparticle and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system to enhance the longer shelf live upon preserving the therapeutic agents 11. With the increase in surfactant concentration, the ph of the nanoemulsion formulation increased. Nanoemulsion is a heterogeneous system composed of one immiscible liquid dispersed as droplets within another liquid. I thank dr sanko nguyen for helping me with thesis writing. To construct the phase diagram, oil sesame oil and smix were mixed thoroughly with the help of magnetic stirrer in different volume ratios from 1. Hemraj chhipa, the energy and resources institute, darbari seth block, ihc complex, lodhi road, new delhi. In this thesis, we address this issue by providing a rationale to synthesize nanoemulsions for both high energy and low energy methods.
Preparation, characterization and stability study of. The overall hypothesis of this dissertation is that eo nanoemulsions can be formulated. Nanoemulgel for transdermal delivery of cyclobenzaprine. Formulation of a novel nanoemulsion system for enhanced. Thermo stability of nanoemulsion differentiates it from. Nanoemulsion are fine oilwater or wateroil depends of type of formulatory system one want to owe dispersion stabilized by an interfacial film of surfactant molecules having droplet covering the size range in nm, due to their characteristic size nanoemulsion appear transparent or translucent to the naked eye 10. Design, development and evaluation of novel nanoemulsion. Refractive index of the nanoemulsion can be determined by abbes type refractometer at 250. Nanoemulsion and nanoemulgel as a topical formulation. However, so far, all nanogels were formed with small molecular weight surfactants, such as sodium dodecyl sulfate sds. This may be due to the increase in surfactant concentration. Received 07 nov 2016 accepted 30 dec 2016 available online 01 jan 2017 citation. D thesis 2015, integral university 71 surfactant with respect to cosurfactant for detailed study of the phase diagrams in nanoemulsion formation.
Thesis formulation and investigation of gelemulsions. Page 25 a brief introduction to methods of preparation, applications and characterization of nanoemulsion drug delivery systems haritha, syed peer basha, koteswara rao p, chakravarthi vedantham nimra college of pharmacy, vijayawada, india. Oilinwater nanoemulsions were evaluated for clarity, precipitation, zeta potential, and droplet size. Nadeem irfan bukhari 4 march 01, 2004 to november 04, 2008 lecturer in pharmaceutics, school of pharmacy, international medical university. Development of nanoemulsionbased delivery systems for.
Development and characterization of a nanoemulsion containing. A thesis presented by jose daniel colmenares araque submitted to the graduate school of the university of massachusetts amherst in partial fulfillment of the requirements for the degree of masters of science september 2015. Use of nanoemulsions as a prophylactic medicated dosage form, a human. Physicalchemical characterisation, acta pharmaceutica hungarica 78 2008 1121 if. Formulation and characterization of nanoemulsion coatings. Apr 08, 2014 an advanced mode of drug delivery system has been developed to overcome the major drawbacks associated with conventional drug delivery systems. Effect of surfactant and oil type on size droplets of. The mean globule size of the nanoemulsion was determined by. Based on the solubility study sesame oil was optimized as an oil phase. Novel formulations of antioxidant and antiinflammatory drugs. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The pressure exerted inside the droplets having curved interface is given by p 2. An advanced mode of drug delivery system has been developed to overcome the major drawbacks associated with conventional drug delivery systems. Nanoemulsion based on sugar fatty esters or on sugar fatty ethers and their uses in the cosmetics, dermatological andor ophthalmological fields.
A new concept of delivery system article pdf available in chronicles of young scientists 12 january 2010 with 8,273 reads how we measure reads. The sample was putted into a 5 ml volumetric flask and the volume was adjusted to 5 ml and shaken homogeneously. Characterization of microemulsions prepared using isopropyl. The nanoemulsion containing tween 80 as surfactant, miglyol 812 as the carrier oil containing 3% beta carotene with surfactanttoemulsion ratio of ser %17. Specifically, we develop a new scaling theory for high energy methods to control the droplet size. This open access thesis is brought to you for free and open access by the. Hcl nanoemulsion formula formulation was transferred into a glass test tube. Current status and future possibilities hemraj chhipa the energy and resources institute, india submission. A nanoemulsion is a colloidal system consisting of mainly oil, surfactant, and water, with high kinetic stability, low viscosity, and is optically transparent, which is very beneficial in various industries, such as dermatological applications mcclements, 2012. Pdf the main subject is the applications of nanoemulsion systems in cosmetics. This thesis shows how a nanoemulsion with good stability and. Biosurfactant stabilized nanoemulsion uq espace university of. Prophylactic agent to fight against bioterr orism attack 24 the nanoemulsion containing antimicrobial agents has proven prophylactic activity to fight with a bioterrorism attack. Cyclobenzaprine hydrochloride nanoemulsion 2 carbopol 934 1 isopropyl alcohol 10 polyethylene glycol 10 triethanolamine 0.
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